A Prospective open labeled randomized clinical trial on Vali Azhal Keel Vayu with Akkini Chooranam

Priyanga, P (2018) A Prospective open labeled randomized clinical trial on Vali Azhal Keel Vayu with Akkini Chooranam. Masters thesis, Government Siddha Medical College, Palayamkottai.

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Abstract

An open labeled randomized clinical study on ‘VALI AZHAL KEEL VAYU’ with reference to its Aetiology, Pathogenesis, Clinical features, diagnosis, investigations and treatment were conducted at Department of Pothu Maruthuvam, Government Siddha Medical College and Hospital, Palayamkottai. This clinical study of Vali Azhal Keel Vayu is done on the basis of reference in Sabapathi manuscript in Noinadal, Noi mudhal naadal Thiratu Part-II, Pg. No. 623. The disease is correlated with Rhematioid arthritis. The trial drug chosen for the clinical study – AKKINI CHOORANAM Dosage of 4.2 gms twice a day with sugar after food (Ref. Koshayi Anuboga Vaithiya Bramma Ragasiyam Part – II, Pg. No. 104). The aetiology, pathology, pathogenesis, clinical features, classification and prognosis of the disease were collected from a number of literatures both in Siddha system as well as in modern system of medicine. For this study, Out of 40 patients, 20 patients were diagnosed clinically and admitted in the In patients ward and treated with trial medicines. Another twenty patients was treated Out patients department. The selection of patients and management of patients during admission and after treatment is carried out under the supervision of Professor, Associate Professor, Lecturers of Department of Pothu Maruthuvam. A case sheet proforma is prepared with particulars focus on Siddha and Modern clinical parameters. Separate cases sheets were maintained for each patient in In-patient ward and their vital signs and symptoms were monitored and recorded daily. The patients were treated with the trial drug AKKINI CHOORANAM. Routine blood examinations, Urine analysis, other specific investigations and radiological investigations were done by modern scientific methods and were considered for diagnosis and to follow the progress of the patients. Siddha diagnosis is made up with the help of Ezhu Udal Kattugal and Envagai Thervugal. Since Vali Azhal Keel Vayu is a chronic disease, it requires treatment for minimum thirty days to minimize the severe pain, tenderness and swelling with slight disappearance of stiffness. The patient is advised to follow up the treatment in Out patient Department. From this study the following datas were clear that disease was more common in female than male. Maximum incidence was in Pitha Kaalam. Clinically marked reduction in the symptoms along with increase sense of well being, decrease in ESR, decrease in symptoms, decrease in the DISEASE ACTIVITY PAIN SCORE OF 28 JOINTS was noted. The patients were observed for a period of 3 months during and after the course of treatment. No signs of complications were observed. Clinically no toxic effects were noticed during the treatment period. The pharamacological evaluation of AKKINI CHOORANAM showed significant anti inflammatory and analgesic activity. No acute toxicity, side effects were noted. Bio chemical analysis of AKKINI CHOORANAM showed the presence of calcium, sulphate, chloride, ferrous iron, starch, tannic acid, amino acids and unsaturated compound. CONCLUSION: In Sabapathy Manuscript was described under Vali Azhal Keel Vayu explains the clinical conditions as rheumatoid arthritis. The lines of this version are well analysed under Siddha and modern parameters and the cases are thoroughly examined with clinical and bio chemical report. Treatment is given on the basis of Mukkutra Theory. The deranged kutrams are made to normal by the trial medicine. The trial medicine, AKKINI CHOORANAM has the taste of kaarupu, inippu according to the taste of individual ingredients. Kaarpu suvai - Has its function of relieving indigestion, flatulence and constipation. Inippu suvai - Regulates the vitiation of Vatham and Pitham. Thus the trial drug based of its suvai acts as an effective anti-arthritic drug. Almost all the cases treated with the trial drug shows considerable improvements. Further follow up of all patients showed a significant relief of their symptoms. 1. 50% of Out patients and 60% of In patients showed Good response. 2. 30% of Out patients and 20% of In patients showed Moderate response. 3. 20% of Out patients and 20% of In patients showed Poor response. I conclude that, this trial drug ‘AKKINI CHOORANAM’ has improved the clinical symptoms of the patients and assured them a better standard of living.

Item Type: Thesis (Masters)
Additional Information: (Reg.No. 321511005)
Uncontrolled Keywords: Vali Azhal Keel Vayu ; Akkini Chooranam ; Prospective open labeled randomized clinical trial.
Subjects: AYUSH > Maruthuvam
Depositing User: Subramani R
Date Deposited: 29 Dec 2018 14:15
Last Modified: 29 Dec 2018 14:15
URI: http://repository-tnmgrmu.ac.in/id/eprint/10216

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