Azhagumani, D (2014) Development and Characterization of Oro Dispersible Tablets of Diltiazem Hydrochloride. Masters thesis, K M College of Pharmacy, Madurai.
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AZHAGUMANI D.pdf Download (1MB) | Preview |
Abstract
The oral route of drug administration is the most important method for administering drugs for systemic effects. Except in certain cases the parenteral route is not routinely used for self administration, e.g. insulin. The topical route of administration has only recently been employed to deliver drugs to the body for systemic effects. The parenteral route of administration is important in treating medical emergencies in which the subject is comatose or cannot swallow. Nevertheless it is probable that at least 90% of all drugs used to provide systemic effects are administered by the oral route. When a new drug is discovered one of the first questions, a pharmaceutical company asks is whether or not the drug can be effectively administered forits intended effect by the oral route. Of drugs that are administered orally, solid oral dosage forms represent the preferred class of products. Tablets and capsules represent unit dosage forms in which usual dose of a drug has been accurately placed. The oro dispersible Tablets (ODT’s) of Diltiazem hydrochloride were prepared by Direct compression method using various super disintegrants. Formulation F8 containing 10%w/v concentration of Cros Povidone with appropriate amount of other excipients were considered to be the optimized formulation with the desired drug release. The oro dispersible Tablet formulation of Diltiazem hydrochloride provides instant relief for migraine sufferers and helps them to resume their normal function as soon as possible. All formulation were found to have homogenic drug distribution with excellent content uniformity. F8 batch contains 10% CP was optimized. Comparative drug release study revealed that the formulated Oro dispersible tablets [ODT’s] release drug more rapidly than the marketed sample. The results of stability studies revealed that the formulation F8 showed no significant variations in all the parameters and was stable for a period of 3 months. The optimized formulation F8 was found to follow First order kinetics, which was revealed by the linearity shown from the plot of logarithm of drug remaining to be released versus time.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Development; Characterization; Oro Dispersible Tablets; Diltiazem ; Hydrochloride. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 05 Jul 2017 09:09 |
| Last Modified: | 15 May 2018 23:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1019 |
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