Shiela Mary, Varghese (2010) Osteoporosis in chronic spinal cord injury and the effect of zoledronic acid. Masters thesis, Christian Medical College, Vellore.
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Abstract
Comprehensive care and early rehabilitation has improved the quality of life of people following spinal cord injury. However osteoporosis among this group of individuals often predisposes them to the risk of secondary fractures and related complications. These are the cause of considerable financial and social burden. The sites and severity of skeletal bone loss can now be more accurately determined with use of densitometry. Bone loss has been reported to occur in the lower extremities mostly and DEXA scan provides a means to predict fracture risk in chronic SCI patients. This can help in planning fracture preventive measures during their rehabilitation. Although various groups of bisphosphonates have been studied in the past for osteoporosis treatment and prophylaxis among SCI patients, the results have shown only a modest potential benefit and the compliance poor for the forms requiring regular oral intake. Zoledronic acid, a newer and more potent bisphosphonate with potential for single dose yearly intravenous infusion has been shown to be beneficial in osteoporosis in postmenopausal women and in liver transplant patients. However, its benefit in osteoporotic chronic spinal cord injured patients needs to be studied. If found beneficial it has the potential to ensure better compliance and fracture prophylaxis in our subset of chronic spinal cord injured patients due to the advantage of yearly dose administration.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Osteoporosis ; chronic spinal cord injury ; zoledronic acid. |
| Subjects: | MEDICAL > Physical Medicine and Rehabilitation |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Nov 2018 02:27 |
| Last Modified: | 25 Nov 2018 02:32 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10113 |
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