Sarah Afreen, - (2017) Effectiveness of mood stabilizer in euthymic BPAD patients: An one year prospective observational study, comparing lithium v/s divalproate sodium. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.
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Abstract
BACKGROUND: Bipolar affective disorder patients, a major mental illness continues to be a distressing disorder. Lithium carbonate and divalproatte sodium remains FDA approved. Studies on its long term outcome, adherence to medication, adverse effects remains less. OBJECTIVE: 1. To evaluate the time for any mood episodes (mania/depression/mixed episodes). 2. To access the severity of the mood episodes. 3. To evaluate for episodes of deliberate self harm. 4. To compare the adherence between lithium and divalproate sodium group. 5. To compare the adverse effect profile between the two groups. 6. To access the functioning between the two study groups. 7. To correlate the new onset manic /depressive episode with serum lithium/dosage of divalproate sodium. METHODOLOGY: We recruited 52 patients each on lithium and Divalproate arm, who qualified for inclusion & exclusion criteria. These patients were followed up for one year in psychiatry OP (initial evaluation 3rd, later 6th, 9th, 12th month periodic evaluation). Socio-demographic details, severity of mood disorders, adherence of medications, adverse effects and functioning were accessed. RESULTS: The socio-demographic variables did not differ between the two groups. The confounding variables (age of onset, number of episodes, previous hospitalisations, polarity of previous episodes, use of psychotrophics) did not differ between the two groups. The duration of mood stabiliser was for a longer period in lithium group. Patients on lithium, on prolonged follow up had less frequent & less severe manic episode, less suicidal risk(trending towards significance). CONCLUSION: There was no difference in terms of frequency of depressive episode, adherence, adverse effects and global functioning between the two groups. But lithium group patients had lesser manic episodes, less severe episodes and low suicidal risk, favouring Lithium to be a better mood stabilizer.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | mood stabilizer ; euthymic BPAD patients lithium ; divalproate sodium ; prospective observational study. |
| Subjects: | MEDICAL > Psychiatry |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Nov 2018 02:22 |
| Last Modified: | 25 Nov 2018 02:22 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10112 |
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