Rohini Ann, Mathew (2016) Red blood cell morphology as a marker of oxidative stress in in early Type 2 Diabetes patients and efficacy of Antioxidants as an add on therapy to standard treatment: A Randomized, Open Label, Comparative Pilot study. Masters thesis, Madras Medical College, Chennai.
|
Text
200600116rohini_ann_mathew.pdf Download (3MB) | Preview |
|
|
Text
200600116rohini_ann_mathew_abstract.pdf Download (7kB) | Preview |
Abstract
OBJECTIVE: To study RBC morphology (crenated edges with Heinz bodies) in Type 2 Diabetes as a marker of oxidative stress and efficacy of Antioxidants as add on therapy to standard treatment. METHODOLOGY: 60 patients with Type2 Diabetes on metformin were randomized equally into study and control groups. 1ml of blood was collected, washed with saline, centrifuged and RBC suspension observed under high power microscope. Study group received Vitamin C (500mg) and Vitamin E (400 I.U) once daily with standard treatment for 8 weeks. Patients were assessed at 4 and 8 weeks for RBC morphology, fasting glucose, Hemoglobin, RBC count and Blood pressure. RESULTS: After 8 weeks, study group in comparison to the control group showed near complete restoration to normal RBCs and significant improvement in fasting glucose, Hemoglobin, RBC count and BP. CONCLUSION: Free radical induced oxidative damage to RBCs leading to hemolysis is the main cause of anemia in these patients, hence RBC morphology can be used as a marker of oxidative stress in Type 2 diabetes. Adding Vitamin C and E to standard treatment is cost effective and novel approach in the management of these patients.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Type 2 diabetes ; Oxidative stress ; RBC morphology ; Antioxidants. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Nov 2018 02:01 |
| Last Modified: | 25 Nov 2018 02:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10109 |
Actions (login required)
 |
View Item |
