Aravapalli, V S A Kumar (2014) Formulation and Evaluation of Escitalopram Oxalate Immediate Release Tablets. Masters thesis, College of Pharmacy, Jaya College of Paramedical Sciences, Chennai.
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Abstract
Escitalopram Oxalate is a class of drug with selective serotonin (5-HT) reuptake inhibitor (SSRIs). SSRIs are broad spectrum antidepressants that are effective for major depressive disorder and several anxiety disorders. The main objective of the present study was to develop a pharmaceutically equivalent, stable, cost effective and quality improved formulation of immediate release tablets of Escitalopram Oxalate using different concentration of superdisintegrants like croscarmellose sodium and sodium starch glycolate. Preformulation studies were performed prior to formulation. The tablets were compressed using microcrystalline cellulose, colloidal silicon dioxide, talc, magnesium stearate and opadry white was used for coating the tablets. The tablets were formulated by wet granulation with non aqueous binder and the fabricated tablets were evaluated for various micromeritic properties like bulk density, tapped density, compressibility index, Hausner’sratio, angle of repose and post compression characteristics like thickness, hardness, friability, disintegration time and drug release. Croscarmellose sodium was used as the disintegrant in the formulation of immediate release tablets of Escitalopram Oxalate. The stability studies were carried out for the optimized batch for six months. The results of the present study showed that among all the formulations, F12 was better in all terms of preformulation and post compression parameters and showed comparably a good dissolution profile like that of the marketed product(cipralex).
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation ; Evaluation ; Escitalopram ; Oxalate Immediate Release Tablets. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 05 Jul 2017 07:27 |
| Last Modified: | 15 May 2018 23:38 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1010 |
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